Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex

P A Gray; J C Rekling; C M Bocchiaro; J L Feldman

Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex

P A Gray, J C Rekling, C M Bocchiaro, J L Feldman

Department of Neuroscience

454 Citations (Scopus)

Abstract

Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.

Original language	English
Journal	Science
Volume	286
Issue number	5444
Pages (from-to)	1566-8
Number of pages	2
ISSN	0036-8075
Publication status	Published - 1999

Cite this

@article{491722f0cde911dd9473000ea68e967b,

title = "Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preB{\"o}tzinger complex",

abstract = "Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preB{\"o}tzinger Complex (preB{\"o}tC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preB{\"o}tC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preB{\"o}tC. Type 1 neurons in the preB{\"o}tC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preB{\"o}tC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.",

author = "Gray, {P A} and Rekling, {J C} and Bocchiaro, {C M} and Feldman, {J L}",

note = "Keywords: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Medulla Oblongata; Mice; Mice, Inbred BALB C; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Neurokinin-1; Receptors, Opioid, mu; Respiratory Mechanics; Substance P; Synaptic Transmission",

year = "1999",

language = "English",

volume = "286",

pages = "1566--8",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5444",

}

TY - JOUR

T1 - Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex

AU - Gray, P A

AU - Rekling, J C

AU - Bocchiaro, C M

AU - Feldman, J L

N1 - Keywords: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Medulla Oblongata; Mice; Mice, Inbred BALB C; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Neurokinin-1; Receptors, Opioid, mu; Respiratory Mechanics; Substance P; Synaptic Transmission

PY - 1999

Y1 - 1999

N2 - Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.

AB - Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.

M3 - Journal article

C2 - 10567264

SN - 0036-8075

VL - 286

SP - 1566

EP - 1568

JO - Science

JF - Science

IS - 5444

ER -

Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex

Abstract

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