@article{491722f0cde911dd9473000ea68e967b,
title = "Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preB{\"o}tzinger complex",
abstract = "Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preB{\"o}tzinger Complex (preB{\"o}tC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preB{\"o}tC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preB{\"o}tC. Type 1 neurons in the preB{\"o}tC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preB{\"o}tC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.",
author = "Gray, {P A} and Rekling, {J C} and Bocchiaro, {C M} and Feldman, {J L}",
note = "Keywords: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Medulla Oblongata; Mice; Mice, Inbred BALB C; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Neurokinin-1; Receptors, Opioid, mu; Respiratory Mechanics; Substance P; Synaptic Transmission",
year = "1999",
language = "English",
volume = "286",
pages = "1566--8",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5444",
}