MiR-EdiTar: A database of predicted A-to-I edited miRNA target sites

TY - JOUR

T1 - MiR-EdiTar

T2 - A database of predicted A-to-I edited miRNA target sites

AU - Laganà, Alessandro

AU - Paone, Alessio

AU - Veneziano, Dario

AU - Cascione, Luciano

AU - Gasparini, Pierluigi

AU - Carasi, Stefania

AU - Russo, Francesco

AU - Nigita, Giovanni

AU - MacCa, Valentina

AU - Giugno, Rosalba

AU - Pulvirenti, Alfredo

AU - Shasha, Dennis

AU - Ferro, Alfredo

AU - Croce, Carlo M.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Motivation: A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones. Results: This work presents miR-EdiTar, a database of predicted A-to-I edited miRNA binding sites. The database contains predicted miRNA binding sites that could be affected by A-to-I editing and sites that could become miRNA binding sites as a result of A-to-I editing.

AB - Motivation: A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones. Results: This work presents miR-EdiTar, a database of predicted A-to-I edited miRNA binding sites. The database contains predicted miRNA binding sites that could be affected by A-to-I editing and sites that could become miRNA binding sites as a result of A-to-I editing.

UR - http://www.scopus.com/inward/record.url?scp=84870428740&partnerID=8YFLogxK

U2 - 10.1093/bioinformatics/bts589

DO - 10.1093/bioinformatics/bts589

M3 - Journal article

C2 - 23044546

AN - SCOPUS:84870428740

SN - 1367-4811

VL - 28

SP - 3166

EP - 3168

JO - Bioinformatics (Online)

JF - Bioinformatics (Online)

IS - 23

ER -