MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

J A Ronald; R Katzenberg; Carsten Haagen Nielsen; H J Jae; L V Hofmann; S S Gambhir

doi:10.1038/gt.2013.24

MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

J A Ronald, R Katzenberg, Carsten Haagen Nielsen, H J Jae, L V Hofmann, S S Gambhir

Department of Biomedical Sciences

5 Citations (Scopus)

Abstract

In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

Original language	English
Journal	Gene Therapy
Volume	20
Pages (from-to)	1006-1013
Number of pages	8
ISSN	0969-7128
DOIs	https://doi.org/10.1038/gt.2013.24
Publication status	Published - 30 May 2013

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title = "MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma",

abstract = "In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P",

author = "Ronald, {J A} and R Katzenberg and Nielsen, {Carsten Haagen} and Jae, {H J} and Hofmann, {L V} and Gambhir, {S S}",

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AU - Ronald, J A

AU - Katzenberg, R

AU - Nielsen, Carsten Haagen

AU - Jae, H J

AU - Hofmann, L V

AU - Gambhir, S S

PY - 2013/5/30

Y1 - 2013/5/30

N2 - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

AB - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

U2 - 10.1038/gt.2013.24

DO - 10.1038/gt.2013.24

M3 - Journal article

C2 - 23719066

SN - 0969-7128

VL - 20

SP - 1006

EP - 1013

JO - Gene Therapy

JF - Gene Therapy

ER -

MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

Abstract

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