MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

TY - JOUR

T1 - MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

AU - Ronald, J A

AU - Katzenberg, R

AU - Nielsen, Carsten Haagen

AU - Jae, H J

AU - Hofmann, L V

AU - Gambhir, S S

PY - 2013/5/30

Y1 - 2013/5/30

N2 - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

AB - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

U2 - 10.1038/gt.2013.24

DO - 10.1038/gt.2013.24

M3 - Journal article

C2 - 23719066

SN - 0969-7128

VL - 20

SP - 1006

EP - 1013

JO - Gene Therapy

JF - Gene Therapy

ER -