TY - JOUR
T1 - MicroProteins
T2 - small size - big impact
AU - Eguen, Teinai Ebimienere
AU - Straub, Daniel
AU - Graeff, Moritz
AU - Wenkel, Stephan
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.
AB - MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.
U2 - 10.1016/j.tplants.2015.05.011
DO - 10.1016/j.tplants.2015.05.011
M3 - Journal article
C2 - 26115780
SN - 1360-1385
VL - 20
SP - 477
EP - 482
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 8
ER -