MicroProteins: small size - big impact

TY - JOUR

T1 - MicroProteins

T2 - small size - big impact

AU - Eguen, Teinai Ebimienere

AU - Straub, Daniel

AU - Graeff, Moritz

AU - Wenkel, Stephan

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.

AB - MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.

U2 - 10.1016/j.tplants.2015.05.011

DO - 10.1016/j.tplants.2015.05.011

M3 - Journal article

C2 - 26115780

SN - 1360-1385

VL - 20

SP - 477

EP - 482

JO - Trends in Plant Science

JF - Trends in Plant Science

IS - 8

ER -