Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Aghiad Ghazal; Mark Gontsarik; Jörg P. Kutter; Josiane P. Lafleur; Davoud Ahmadvand; Ana Labrador; Stefan Salentinig; Anan Yaghmur

doi:10.1021/acs.jpclett.6b02468

Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Aghiad Ghazal, Mark Gontsarik, Jörg P. Kutter, Josiane P. Lafleur, Davoud Ahmadvand, Ana Labrador, Stefan Salentinig, Anan Yaghmur

Xray and Neutron Science

19 Citations (Scopus)

Abstract

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

Original language	English
Journal	The Journal of Physical Chemistry Letters
Volume	17
Pages (from-to)	73-79
Number of pages	7
ISSN	1948-7185
DOIs	https://doi.org/10.1021/acs.jpclett.6b02468
Publication status	Published - 5 Jan 2017

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Cite this

Ghazal, A., Gontsarik, M., Kutter, J. P., Lafleur, J. P., Ahmadvand, D., Labrador, A., Salentinig, S., & Yaghmur, A. (2017). Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. The Journal of Physical Chemistry Letters, 17, 73-79. https://doi.org/10.1021/acs.jpclett.6b02468

Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. / Ghazal, Aghiad; Gontsarik, Mark; Kutter, Jörg P. et al.

In: The Journal of Physical Chemistry Letters, Vol. 17, 05.01.2017, p. 73-79.

Research output: Contribution to journal › Journal article › Research › peer-review

Ghazal, A, Gontsarik, M, Kutter, JP, Lafleur, JP, Ahmadvand, D, Labrador, A, Salentinig, S & Yaghmur, A 2017, 'Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study', The Journal of Physical Chemistry Letters, vol. 17, pp. 73-79. https://doi.org/10.1021/acs.jpclett.6b02468

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abstract = "A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.",

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