Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Aghiad Ghazal; Mark Gontsarik; Jörg P. Kutter; Josiane P. Lafleur; Davoud Ahmadvand; Ana Labrador; Stefan Salentinig; Anan Yaghmur

doi:10.1021/acs.jpclett.6b02468

Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Aghiad Ghazal, Mark Gontsarik, Jörg P. Kutter, Josiane P. Lafleur, Davoud Ahmadvand, Ana Labrador, Stefan Salentinig, Anan Yaghmur

X-ray and Neutron Science

19 Citationer (Scopus)

Abstract

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

Originalsprog	Engelsk
Tidsskrift	The Journal of Physical Chemistry Letters
Vol/bind	17
Sider (fra-til)	73-79
Antal sider	7
ISSN	1948-7185
DOI	https://doi.org/10.1021/acs.jpclett.6b02468
Status	Udgivet - 5 jan. 2017

Adgang til dokumentet

10.1021/acs.jpclett.6b02468

acs.jpclett.6b02468Forlagets udgivne version, 2,48 MB

Citationsformater

Ghazal, A., Gontsarik, M., Kutter, J. P., Lafleur, J. P., Ahmadvand, D., Labrador, A., Salentinig, S., & Yaghmur, A. (2017). Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. The Journal of Physical Chemistry Letters, 17, 73-79. https://doi.org/10.1021/acs.jpclett.6b02468

Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. / Ghazal, Aghiad; Gontsarik, Mark; Kutter, Jörg P. et al.

I: The Journal of Physical Chemistry Letters, Bind 17, 05.01.2017, s. 73-79.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ghazal, A, Gontsarik, M, Kutter, JP, Lafleur, JP, Ahmadvand, D, Labrador, A, Salentinig, S & Yaghmur, A 2017, 'Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study', The Journal of Physical Chemistry Letters, bind 17, s. 73-79. https://doi.org/10.1021/acs.jpclett.6b02468

@article{d43d74b7d36540ff8257b09b8084dfc2,

title = "Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study",

abstract = "A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.",

author = "Aghiad Ghazal and Mark Gontsarik and Kutter, {J{\"o}rg P.} and Lafleur, {Josiane P.} and Davoud Ahmadvand and Ana Labrador and Stefan Salentinig and Anan Yaghmur",

year = "2017",

month = jan,

day = "5",

doi = "10.1021/acs.jpclett.6b02468",

language = "English",

volume = "17",

pages = "73--79",

journal = "Journal of Physical Chemistry Letters",

issn = "1948-7185",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles

T2 - A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

AU - Ghazal, Aghiad

AU - Gontsarik, Mark

AU - Kutter, Jörg P.

AU - Lafleur, Josiane P.

AU - Ahmadvand, Davoud

AU - Labrador, Ana

AU - Salentinig, Stefan

AU - Yaghmur, Anan

PY - 2017/1/5

Y1 - 2017/1/5

N2 - A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

AB - A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

U2 - 10.1021/acs.jpclett.6b02468

DO - 10.1021/acs.jpclett.6b02468

M3 - Journal article

C2 - 27936765

SN - 1948-7185

VL - 17

SP - 73

EP - 79

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

ER -