Methodological pitfalls in early detection studies–the NAPE Lecture 2002

Friis Svein; Larsen Tor Ketil; Ingrid Melle; Stein Opjordsmoen; Jan Olav Johannessen; Ulrik Helt Haahr; Erik Simonsen; Bjørn Rishovd Rund; Per Vaglum; Thomas McGlashan

doi:10.1034/j.1600-0447.2003.02600.x

Methodological pitfalls in early detection studies–the NAPE Lecture 2002

Friis Svein, Larsen Tor Ketil, Ingrid Melle, Stein Opjordsmoen, Jan Olav Johannessen, Ulrik Helt Haahr, Erik Simonsen, Bjørn Rishovd Rund, Per Vaglum, Thomas McGlashan

Department of Clinical Medicine

83 Citations (Scopus)

Abstract

Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Original language	English
Book series	Acta Psychiatrica Scandinavica. Supplementum
Volume	107
Pages (from-to)	3-9
Number of pages	7
ISSN	0065-1591
DOIs	https://doi.org/10.1034/j.1600-0447.2003.02600.x
Publication status	Published - 2003

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Cite this

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title = "Methodological pitfalls in early detection studies–the NAPE Lecture 2002",

abstract = "Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)",

keywords = "confounding factors, early intervention, psychotic disorders, reproducibility of results, research",

author = "Friis Svein and {Tor Ketil}, Larsen and Ingrid Melle and Stein Opjordsmoen and Johannessen, {Jan Olav} and Haahr, {Ulrik Helt} and Erik Simonsen and Rund, {Bj{\o}rn Rishovd} and Per Vaglum and Thomas McGlashan",

year = "2003",

doi = "10.1034/j.1600-0447.2003.02600.x",

language = "English",

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T1 - Methodological pitfalls in early detection studies–the NAPE Lecture 2002

AU - Svein, Friis

AU - Tor Ketil, Larsen

AU - Melle, Ingrid

AU - Opjordsmoen, Stein

AU - Johannessen, Jan Olav

AU - Haahr, Ulrik Helt

AU - Simonsen, Erik

AU - Rund, Bjørn Rishovd

AU - Vaglum, Per

AU - McGlashan, Thomas

PY - 2003

Y1 - 2003

N2 - Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

AB - Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

KW - confounding factors

KW - early intervention

KW - psychotic disorders

KW - reproducibility of results

KW - research

U2 - 10.1034/j.1600-0447.2003.02600.x

DO - 10.1034/j.1600-0447.2003.02600.x

M3 - Journal article

SN - 0065-1591

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SP - 3

EP - 9

JO - Acta Psychiatrica Scandinavica, Supplement

JF - Acta Psychiatrica Scandinavica, Supplement

ER -