Methodological pitfalls in early detection studies–the NAPE Lecture 2002

Friis Svein; Larsen Tor Ketil; Ingrid Melle; Stein Opjordsmoen; Jan Olav Johannessen; Ulrik Helt Haahr; Erik Simonsen; Bjørn Rishovd Rund; Per Vaglum; Thomas McGlashan

doi:10.1034/j.1600-0447.2003.02600.x

Methodological pitfalls in early detection studies–the NAPE Lecture 2002

Friis Svein, Larsen Tor Ketil, Ingrid Melle, Stein Opjordsmoen, Jan Olav Johannessen, Ulrik Helt Haahr, Erik Simonsen, Bjørn Rishovd Rund, Per Vaglum, Thomas McGlashan

Institut for Klinisk Medicin

83 Citationer (Scopus)

Abstract

Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Originalsprog	Engelsk
Bogserie	Acta Psychiatrica Scandinavica. Supplementum
Vol/bind	107
Sider (fra-til)	3-9
Antal sider	7
ISSN	0065-1591
DOI	https://doi.org/10.1034/j.1600-0447.2003.02600.x
Status	Udgivet - 2003

Emneord

confounding factors
early intervention
psychotic disorders
reproducibility of results
research

Adgang til dokumentet

10.1034/j.1600-0447.2003.02600.x

Citationsformater

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abstract = "Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)",

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T1 - Methodological pitfalls in early detection studies–the NAPE Lecture 2002

AU - Svein, Friis

AU - Tor Ketil, Larsen

AU - Melle, Ingrid

AU - Opjordsmoen, Stein

AU - Johannessen, Jan Olav

AU - Haahr, Ulrik Helt

AU - Simonsen, Erik

AU - Rund, Bjørn Rishovd

AU - Vaglum, Per

AU - McGlashan, Thomas

PY - 2003

Y1 - 2003

N2 - Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

AB - Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

KW - confounding factors

KW - early intervention

KW - psychotic disorders

KW - reproducibility of results

KW - research

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DO - 10.1034/j.1600-0447.2003.02600.x

M3 - Journal article

SN - 0065-1591

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EP - 9

JO - Acta Psychiatrica Scandinavica, Supplement

JF - Acta Psychiatrica Scandinavica, Supplement

ER -