Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat

Steen Seier Poulsen; J Thulesen; L Christensen; E Nexo; L Thim

Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat

Steen Seier Poulsen, J Thulesen, L Christensen, E Nexo, L Thim

Endocrinology and Metabolism

67 Citations (Scopus)

Abstract

Trefoil factors (TFFs) are peptides produced by mucus-secreting cells in the gastrointestinal tract. A functional association between these peptides and mucus, leading to stabilisation of the viscoelastic gel overlying the epithelia, has been suggested. Both oral and parenteral administration of the peptides increase the resistance of the gastric mucosa.

Original language	English
Journal	Gut
Volume	45
Issue number	4
Pages (from-to)	516-22
Number of pages	7
ISSN	0017-5749
Publication status	Published - 1 Oct 1999

Keywords

Administration, Cutaneous
Administration, Oral
Animals
Digestive System
Duodenal Ulcer
Female
Growth Substances
Mucins
Muscle Proteins
Neuropeptides
Peptides
Rats
Rats, Sprague-Dawley
Stomach Ulcer
Wound Healing

Cite this

@article{f6427a0e25b84109b6c8322da36f6099,

title = "Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat",

abstract = "Trefoil factors (TFFs) are peptides produced by mucus-secreting cells in the gastrointestinal tract. A functional association between these peptides and mucus, leading to stabilisation of the viscoelastic gel overlying the epithelia, has been suggested. Both oral and parenteral administration of the peptides increase the resistance of the gastric mucosa.",

keywords = "Administration, Cutaneous, Administration, Oral, Animals, Digestive System, Duodenal Ulcer, Female, Growth Substances, Mucins, Muscle Proteins, Neuropeptides, Peptides, Rats, Rats, Sprague-Dawley, Stomach Ulcer, Wound Healing",

author = "Poulsen, {Steen Seier} and J Thulesen and L Christensen and E Nexo and L Thim",

year = "1999",

month = oct,

day = "1",

language = "English",

volume = "45",

pages = "516--22",

journal = "Gut",

issn = "0017-5749",

publisher = "B M J Group",

number = "4",

}

TY - JOUR

T1 - Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat

AU - Poulsen, Steen Seier

AU - Thulesen, J

AU - Christensen, L

AU - Nexo, E

AU - Thim, L

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Trefoil factors (TFFs) are peptides produced by mucus-secreting cells in the gastrointestinal tract. A functional association between these peptides and mucus, leading to stabilisation of the viscoelastic gel overlying the epithelia, has been suggested. Both oral and parenteral administration of the peptides increase the resistance of the gastric mucosa.

AB - Trefoil factors (TFFs) are peptides produced by mucus-secreting cells in the gastrointestinal tract. A functional association between these peptides and mucus, leading to stabilisation of the viscoelastic gel overlying the epithelia, has been suggested. Both oral and parenteral administration of the peptides increase the resistance of the gastric mucosa.

KW - Administration, Cutaneous

KW - Administration, Oral

KW - Animals

KW - Digestive System

KW - Duodenal Ulcer

KW - Female

KW - Growth Substances

KW - Mucins

KW - Muscle Proteins

KW - Neuropeptides

KW - Peptides

KW - Rats

KW - Rats, Sprague-Dawley

KW - Stomach Ulcer

KW - Wound Healing

M3 - Journal article

C2 - 10486358

SN - 0017-5749

VL - 45

SP - 516

EP - 522

JO - Gut

JF - Gut

IS - 4

ER -

Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat

Abstract

Keywords

Fingerprint

Cite this