Messenger RNA surveillance: neutralizing natural nonsense.

TY - JOUR

T1 - Messenger RNA surveillance: neutralizing natural nonsense.

AU - Weischelfeldt, Joachim Lütken

AU - Lykke-Andersen, Jens

AU - Porse, Bo

N1 - Keywords: Animals; Caenorhabditis elegans; Codon, Nonsense; Gene Expression Regulation; Mice; Models, Biological; Pseudogenes; RNA Helicases; RNA Stability; RNA, Small Nucleolar

PY - 2005

Y1 - 2005

N2 - Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.

AB - Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.

U2 - 10.1016/j.cub.2005.07.002

DO - 10.1016/j.cub.2005.07.002

M3 - Journal article

C2 - 16051166

SN - 0960-9822

VL - 15

SP - R559-62

JO - Current Biology

JF - Current Biology

IS - 14

ER -