Abstract
The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.
| Original language | English |
|---|---|
| Journal | BBA General Subjects |
| Volume | 728 |
| Issue number | 3 |
| Pages (from-to) | 455-9 |
| Number of pages | 5 |
| ISSN | 0304-4165 |
| Publication status | Published - 9 Mar 1983 |
Keywords
- Animals
- Biological Transport, Active
- Bufo bufo
- Cell Membrane
- Chlorides
- Computers
- Epithelium
- Kinetics
- Membrane Potentials
- Skin Physiological Phenomena