Membrane potential plays a dual role for chloride transport across toad skin

Erik Hviid Larsen; B E Rasmussen

Membrane potential plays a dual role for chloride transport across toad skin

Molecular Integrative Physiology

8 Citationer (Scopus)

Abstract

The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

Originalsprog	Engelsk
Tidsskrift	BBA General Subjects
Vol/bind	728
Udgave nummer	3
Sider (fra-til)	455-9
Antal sider	5
ISSN	0304-4165
Status	Udgivet - 9 mar. 1983

Citationsformater

@article{a1f6f9eb0575406c877bca8ebce19fc2,

title = "Membrane potential plays a dual role for chloride transport across toad skin",

abstract = "The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.",

keywords = "Animals, Biological Transport, Active, Bufo bufo, Cell Membrane, Chlorides, Computers, Epithelium, Kinetics, Membrane Potentials, Skin Physiological Phenomena",

author = "Larsen, {Erik Hviid} and Rasmussen, {B E}",

year = "1983",

month = mar,

day = "9",

language = "English",

volume = "728",

pages = "455--9",

journal = "BBA General Subjects",

issn = "0304-4165",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Membrane potential plays a dual role for chloride transport across toad skin

AU - Larsen, Erik Hviid

AU - Rasmussen, B E

PY - 1983/3/9

Y1 - 1983/3/9

N2 - The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

AB - The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

KW - Animals

KW - Biological Transport, Active

KW - Bufo bufo

KW - Cell Membrane

KW - Chlorides

KW - Computers

KW - Epithelium

KW - Kinetics

KW - Membrane Potentials

KW - Skin Physiological Phenomena

M3 - Journal article

C2 - 6402013

SN - 0304-4165

VL - 728

SP - 455

EP - 459

JO - BBA General Subjects

JF - BBA General Subjects

IS - 3

ER -

Membrane potential plays a dual role for chloride transport across toad skin

Abstract

Fingeraftryk

Citationsformater