Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Renan Marrichi Mauch; Peter Østrup Jensen; Claus Moser; Carlos Emilio Levy; Niels Høiby

doi:10.1016/j.jcf.2017.08.012

Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Renan Marrichi Mauch, Peter Østrup Jensen, Claus Moser, Carlos Emilio Levy, Niels Høiby

13 Citations (Scopus)

Abstract

P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

Original language	English
Journal	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume	17
Issue number	2
Pages (from-to)	143-152
ISSN	1569-1993
DOIs	https://doi.org/10.1016/j.jcf.2017.08.012
Publication status	Published - Mar 2018

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title = "Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis",

abstract = "P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.",

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T1 - Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

AU - Mauch, Renan Marrichi

AU - Jensen, Peter Østrup

AU - Moser, Claus

AU - Levy, Carlos Emilio

AU - Høiby, Niels

PY - 2018/3

Y1 - 2018/3

N2 - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

AB - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

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DO - 10.1016/j.jcf.2017.08.012

M3 - Review

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VL - 17

SP - 143

EP - 152

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 2

ER -

Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Abstract

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