TY - JOUR
T1 - Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis
AU - Mauch, Renan Marrichi
AU - Jensen, Peter Østrup
AU - Moser, Claus
AU - Levy, Carlos Emilio
AU - Høiby, Niels
N1 - Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.
AB - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.
U2 - 10.1016/j.jcf.2017.08.012
DO - 10.1016/j.jcf.2017.08.012
M3 - Review
C2 - 29033275
SN - 1569-1993
VL - 17
SP - 143
EP - 152
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 2
ER -