Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

TY - JOUR

T1 - Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

AU - Lund, Michael Taulo

AU - Taudorf, Lærke

AU - Hartmann, Bolette

AU - Helge, Jørn Wulff

AU - Holst, Jens Juul

AU - Dela, Flemming

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.

AB - Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.

KW - Faculty of Health and Medical Sciences

KW - GLP-1

KW - Insulin

KW - Exercise

KW - Training

KW - Incretin

KW - Glucose

U2 - 10.1007/s00421-013-2711-y

DO - 10.1007/s00421-013-2711-y

M3 - Journal article

C2 - 23979179

SN - 1439-6319

VL - 113

SP - 2737

EP - 2747

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 11

ER -