Maturation of the gut microbiome and risk of asthma in childhood

Jakob Stokholm; Martin J. Blaser; Jonathan Thorsen; Morten Arendt Rasmussen; Johannes Eichler Waage; Rebecca K. Vinding; Ann-Marie Malby Schoos; Asja Kunøe; Nadia R. Fink; Bo L. Chawes; Klaus Bønnelykke; Asker Daniel Brejnrod; Martin Steen Mortensen; Waleed Abu Al-Soud; Søren Johannes Sørensen; Hans Bisgaard

doi:10.1038/s41467-017-02573-2

Maturation of the gut microbiome and risk of asthma in childhood

Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten Arendt Rasmussen, Johannes Eichler Waage, Rebecca K. Vinding, Ann-Marie Malby Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker Daniel Brejnrod, Martin Steen Mortensen, Waleed Abu Al-Soud, Søren Johannes Sørensen, Hans Bisgaard

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Abstract

The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

Original language	English
Article number	141
Journal	Nature Communications
Volume	9
Number of pages	10
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-017-02573-2
Publication status	Published - 1 Dec 2018

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Stokholm_2018_Maturation_of_the_gutFinal published version, 1.2 MBLicence: CC BY

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Stokholm, J., Blaser, M. J., Thorsen, J., Rasmussen, M. A., Waage, J. E., Vinding, R. K., Schoos, A.-M. M., Kunøe, A., Fink, N. R., Chawes, B. L., Bønnelykke, K., Brejnrod, A. D., Mortensen, M. S., Abu Al-Soud, W., Sørensen, S. J., & Bisgaard, H. (2018). Maturation of the gut microbiome and risk of asthma in childhood. Nature Communications, 9, Article 141. https://doi.org/10.1038/s41467-017-02573-2

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title = "Maturation of the gut microbiome and risk of asthma in childhood",

abstract = "The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.",

author = "Jakob Stokholm and Blaser, {Martin J.} and Jonathan Thorsen and Rasmussen, {Morten Arendt} and Waage, {Johannes Eichler} and Vinding, {Rebecca K.} and Schoos, {Ann-Marie Malby} and Asja Kun{\o}e and Fink, {Nadia R.} and Chawes, {Bo L.} and Klaus B{\o}nnelykke and Brejnrod, {Asker Daniel} and Mortensen, {Martin Steen} and {Abu Al-Soud}, Waleed and S{\o}rensen, {S{\o}ren Johannes} and Hans Bisgaard",

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AU - Stokholm, Jakob

AU - Blaser, Martin J.

AU - Thorsen, Jonathan

AU - Rasmussen, Morten Arendt

AU - Waage, Johannes Eichler

AU - Vinding, Rebecca K.

AU - Schoos, Ann-Marie Malby

AU - Kunøe, Asja

AU - Fink, Nadia R.

AU - Chawes, Bo L.

AU - Bønnelykke, Klaus

AU - Brejnrod, Asker Daniel

AU - Mortensen, Martin Steen

AU - Abu Al-Soud, Waleed

AU - Sørensen, Søren Johannes

AU - Bisgaard, Hans

N1 - Publisher Correction: Maturation of the gut microbiome and risk of asthma in childhood

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

AB - The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

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DO - 10.1038/s41467-017-02573-2

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VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 141

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Maturation of the gut microbiome and risk of asthma in childhood

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