Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Ditte Marie Bertelsen; Jesper Skov Neergaard; Cecilie Liv Bager; Signe Holm Nielsen; Niels Henry Secher; Jesper Hastrup Svendsen; Asger Reinstrup Bihlet; Jeppe Ragnar Andersen; Morten Asser Karsdal; Claus Christiansen; Henning Bay Nielsen

doi:10.1038/s41598-018-23458-4

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Ditte Marie Bertelsen, Jesper Skov Neergaard, Cecilie Liv Bager, Signe Holm Nielsen, Niels Henry Secher, Jesper Hastrup Svendsen, Asger Reinstrup Bihlet, Jeppe Ragnar Andersen, Morten Asser Karsdal, Claus Christiansen, Henning Bay Nielsen

Department of Clinical Medicine

8 Citations (Scopus)

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Abstract

Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.

Original language	English
Article number	5371
Journal	Scientific Reports
Volume	8
Number of pages	7
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-018-23458-4
Publication status	Published - 1 Dec 2018

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Bertelsen, D. M., Neergaard, J. S., Bager, C. L., Nielsen, S. H., Secher, N. H., Svendsen, J. H., Bihlet, A. R., Andersen, J. R., Karsdal, M. A., Christiansen, C., & Nielsen, H. B. (2018). Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women. Scientific Reports, 8, Article 5371. https://doi.org/10.1038/s41598-018-23458-4

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women. / Bertelsen, Ditte Marie; Neergaard, Jesper Skov; Bager, Cecilie Liv et al.
In: Scientific Reports, Vol. 8, 5371, 01.12.2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Bertelsen, DM, Neergaard, JS, Bager, CL, Nielsen, SH, Secher, NH, Svendsen, JH, Bihlet, AR, Andersen, JR, Karsdal, MA, Christiansen, C & Nielsen, HB 2018, 'Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women', Scientific Reports, vol. 8, 5371. https://doi.org/10.1038/s41598-018-23458-4

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abstract = "Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.",

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AU - Bertelsen, Ditte Marie

AU - Neergaard, Jesper Skov

AU - Bager, Cecilie Liv

AU - Nielsen, Signe Holm

AU - Secher, Niels Henry

AU - Svendsen, Jesper Hastrup

AU - Bihlet, Asger Reinstrup

AU - Andersen, Jeppe Ragnar

AU - Karsdal, Morten Asser

AU - Christiansen, Claus

AU - Nielsen, Henning Bay

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N2 - Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.

AB - Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.

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DO - 10.1038/s41598-018-23458-4

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Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Abstract

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