Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients

Ole B Christiansen; Astrid M Kolte; Mette Dahl; Elisabeth C Larsen; Rudi Steffensen; Henriette S Nielsen; Thomas V Hviid

doi:10.1016/j.humimm.2012.04.014

Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients

Ole B Christiansen, Astrid M Kolte, Mette Dahl, Elisabeth C Larsen, Rudi Steffensen, Henriette S Nielsen, Thomas V Hviid

43 Citations (Scopus)

Abstract

Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p

Original language	English
Journal	Human Immunology
Volume	73
Issue number	7
Pages (from-to)	699-705
Number of pages	7
ISSN	0198-8859
DOIs	https://doi.org/10.1016/j.humimm.2012.04.014
Publication status	Published - Jul 2012

Keywords

Abortion, Habitual
Alleles
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
H-Y Antigen
HLA-G Antigens
Histocompatibility Antigens Class II
Homozygote
Humans
Immunity
Infant, Low Birth Weight
Infant, Newborn
Male
Mutagenesis, Insertional
Polymorphism, Genetic
Protein Binding

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Christiansen, O. B., Kolte, A. M., Dahl, M., Larsen, E. C., Steffensen, R., Nielsen, H. S., & Hviid, T. V. (2012). Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. Human Immunology, 73(7), 699-705. https://doi.org/10.1016/j.humimm.2012.04.014

Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. / Christiansen, Ole B; Kolte, Astrid M; Dahl, Mette et al.

In: Human Immunology, Vol. 73, No. 7, 07.2012, p. 699-705.

Research output: Contribution to journal › Journal article › Research › peer-review

Christiansen, OB, Kolte, AM, Dahl, M, Larsen, EC, Steffensen, R, Nielsen, HS & Hviid, TV 2012, 'Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients', Human Immunology, vol. 73, no. 7, pp. 699-705. https://doi.org/10.1016/j.humimm.2012.04.014

Christiansen OB, Kolte AM, Dahl M, Larsen EC, Steffensen R, Nielsen HS et al. Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. Human Immunology. 2012 Jul;73(7):699-705. doi: 10.1016/j.humimm.2012.04.014

Christiansen, Ole B ; Kolte, Astrid M ; Dahl, Mette et al. / Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. In: Human Immunology. 2012 ; Vol. 73, No. 7. pp. 699-705.

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abstract = "Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p",

keywords = "Abortion, Habitual, Alleles, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, H-Y Antigen, HLA-G Antigens, Histocompatibility Antigens Class II, Homozygote, Humans, Immunity, Infant, Low Birth Weight, Infant, Newborn, Male, Mutagenesis, Insertional, Polymorphism, Genetic, Protein Binding",

author = "Christiansen, {Ole B} and Kolte, {Astrid M} and Mette Dahl and Larsen, {Elisabeth C} and Rudi Steffensen and Nielsen, {Henriette S} and Hviid, {Thomas V}",

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AU - Christiansen, Ole B

AU - Kolte, Astrid M

AU - Dahl, Mette

AU - Larsen, Elisabeth C

AU - Steffensen, Rudi

AU - Nielsen, Henriette S

AU - Hviid, Thomas V

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KW - Genetic Predisposition to Disease

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KW - Infant, Newborn

KW - Male

KW - Mutagenesis, Insertional

KW - Polymorphism, Genetic

KW - Protein Binding

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