Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients

Ole B Christiansen; Astrid M Kolte; Mette Dahl; Elisabeth C Larsen; Rudi Steffensen; Henriette S Nielsen; Thomas V Hviid

doi:10.1016/j.humimm.2012.04.014

Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients

Ole B Christiansen, Astrid M Kolte, Mette Dahl, Elisabeth C Larsen, Rudi Steffensen, Henriette S Nielsen, Thomas V Hviid

43 Citationer (Scopus)

Abstract

Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p

Originalsprog	Engelsk
Tidsskrift	Human Immunology
Vol/bind	73
Udgave nummer	7
Sider (fra-til)	699-705
Antal sider	7
ISSN	0198-8859
DOI	https://doi.org/10.1016/j.humimm.2012.04.014
Status	Udgivet - jul. 2012

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10.1016/j.humimm.2012.04.014

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Citationsformater

Christiansen, O. B., Kolte, A. M., Dahl, M., Larsen, E. C., Steffensen, R., Nielsen, H. S., & Hviid, T. V. (2012). Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. Human Immunology, 73(7), 699-705. https://doi.org/10.1016/j.humimm.2012.04.014

Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. / Christiansen, Ole B; Kolte, Astrid M; Dahl, Mette et al.

I: Human Immunology, Bind 73, Nr. 7, 07.2012, s. 699-705.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Christiansen, OB, Kolte, AM, Dahl, M, Larsen, EC, Steffensen, R, Nielsen, HS & Hviid, TV 2012, 'Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients', Human Immunology, bind 73, nr. 7, s. 699-705. https://doi.org/10.1016/j.humimm.2012.04.014

Christiansen OB, Kolte AM, Dahl M, Larsen EC, Steffensen R, Nielsen HS et al. Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. Human Immunology. 2012 jul.;73(7):699-705. doi: 10.1016/j.humimm.2012.04.014

Christiansen, Ole B ; Kolte, Astrid M ; Dahl, Mette et al. / Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients. I: Human Immunology. 2012 ; Bind 73, Nr. 7. s. 699-705.

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abstract = "Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p",

keywords = "Abortion, Habitual, Alleles, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, H-Y Antigen, HLA-G Antigens, Histocompatibility Antigens Class II, Homozygote, Humans, Immunity, Infant, Low Birth Weight, Infant, Newborn, Male, Mutagenesis, Insertional, Polymorphism, Genetic, Protein Binding",

author = "Christiansen, {Ole B} and Kolte, {Astrid M} and Mette Dahl and Larsen, {Elisabeth C} and Rudi Steffensen and Nielsen, {Henriette S} and Hviid, {Thomas V}",

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AU - Christiansen, Ole B

AU - Kolte, Astrid M

AU - Dahl, Mette

AU - Larsen, Elisabeth C

AU - Steffensen, Rudi

AU - Nielsen, Henriette S

AU - Hviid, Thomas V

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AB - Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p

KW - Abortion, Habitual

KW - Alleles

KW - DNA Mutational Analysis

KW - Female

KW - Genetic Predisposition to Disease

KW - H-Y Antigen

KW - HLA-G Antigens

KW - Histocompatibility Antigens Class II

KW - Homozygote

KW - Humans

KW - Immunity

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Male

KW - Mutagenesis, Insertional

KW - Polymorphism, Genetic

KW - Protein Binding

U2 - 10.1016/j.humimm.2012.04.014

DO - 10.1016/j.humimm.2012.04.014

M3 - Journal article

C2 - 22537754

SN - 0198-8859

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