Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

Jolene Lee Masters Pedersen; Esben Budtz-Joergensen; Naja Hulvej Rod; T.I. Sorensen; E.L. Mortensen; H. Bruunsgaard; R Lund

Abstract

Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

Original language	English
Publication date	2015
Publication status	Published - 2015
Event	Gerontological Society of America: 68th Annual Meeting - Orlando, Florida, United States Duration: 18 Nov 2015 → …

Conference

Conference	Gerontological Society of America: 68th Annual Meeting
Country/Territory	United States
City	Orlando, Florida
Period	18/11/2015 → …

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http://gerontologist.oxfordjournals.org/content/55/Suppl_2/167.1.full.pdf+html

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Pedersen, J. L. M., Budtz-Joergensen, E., Rod, N. H., Sorensen, T. I., Mortensen, E. L., Bruunsgaard, H., & Lund, R. (2015). Maternal Body Weight and Inflammation Among Offspring in Late Middle Age. Abstract from Gerontological Society of America: 68th Annual Meeting, Orlando, Florida, United States. http://gerontologist.oxfordjournals.org/content/55/Suppl_2/167.1.full.pdf+html

Maternal Body Weight and Inflammation Among Offspring in Late Middle Age. / Pedersen, Jolene Lee Masters; Budtz-Joergensen, Esben ; Rod, Naja Hulvej et al.

2015. Abstract from Gerontological Society of America: 68th Annual Meeting, Orlando, Florida, United States.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

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abstract = "Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring{\textquoteright}s BMI in adulthood but not through offspring size at birth.",

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T1 - Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

AU - Pedersen, Jolene Lee Masters

AU - Budtz-Joergensen, Esben

AU - Rod, Naja Hulvej

AU - Sorensen, T.I.

AU - Mortensen, E.L.

AU - Bruunsgaard, H.

AU - Lund, R

PY - 2015

Y1 - 2015

N2 - Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

AB - Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

M3 - Conference abstract for conference

T2 - Gerontological Society of America: 68th Annual Meeting

Y2 - 18 November 2015

ER -

Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

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