Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

Jolene Lee Masters Pedersen; Esben Budtz-Joergensen; Naja Hulvej Rod; T.I. Sorensen; E.L. Mortensen; H. Bruunsgaard; R Lund

Abstract

Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

Originalsprog	Engelsk
Publikationsdato	2015
Status	Udgivet - 2015
Begivenhed	Gerontological Society of America: 68th Annual Meeting - Orlando, Florida, USA Varighed: 18 nov. 2015 → …

Konference

Konference	Gerontological Society of America: 68th Annual Meeting
Land/Område	USA
By	Orlando, Florida
Periode	18/11/2015 → …

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http://gerontologist.oxfordjournals.org/content/55/Suppl_2/167.1.full.pdf+html

Citationsformater

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abstract = "Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring{\textquoteright}s BMI in adulthood but not through offspring size at birth.",

author = "Pedersen, {Jolene Lee Masters} and Esben Budtz-Joergensen and Rod, {Naja Hulvej} and T.I. Sorensen and E.L. Mortensen and H. Bruunsgaard and R Lund",

year = "2015",

language = "English",

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TY - ABST

T1 - Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

AU - Pedersen, Jolene Lee Masters

AU - Budtz-Joergensen, Esben

AU - Rod, Naja Hulvej

AU - Sorensen, T.I.

AU - Mortensen, E.L.

AU - Bruunsgaard, H.

AU - Lund, R

PY - 2015

Y1 - 2015

N2 - Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

AB - Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.

M3 - Conference abstract for conference

T2 - Gerontological Society of America: 68th Annual Meeting

Y2 - 18 November 2015

ER -

Maternal Body Weight and Inflammation Among Offspring in Late Middle Age

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