Malignant lymphoma of the lacrimal gland: a nation-based study

TY - JOUR

T1 - Malignant lymphoma of the lacrimal gland

T2 - a nation-based study

AU - Rasmussen, Peter Kristian

AU - Ralfkiaer, Elisabeth

AU - Prause, Jan Ulrik

AU - Sjö, Lene D

AU - Siersma, Volkert D

AU - Heegaard, Steffen

PY - 2011/10

Y1 - 2011/10

N2 - Objective: To characterize the clinicopathologic features of lacrimal gland lymphoma. Methods: All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected. Results: Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43- 87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%. Conclusions: Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.

AB - Objective: To characterize the clinicopathologic features of lacrimal gland lymphoma. Methods: All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected. Results: Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43- 87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%. Conclusions: Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Eye Neoplasms

KW - Female

KW - Humans

KW - Lacrimal Apparatus Diseases

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Lymphoma, B-Cell

KW - Lymphoma, Follicular

KW - Lymphoma, Mantle-Cell

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Registries

KW - Survival Rate

KW - Tomography, X-Ray Computed

U2 - 10.1001/archophthalmol.2011.270

DO - 10.1001/archophthalmol.2011.270

M3 - Journal article

C2 - 21987669

SN - 2168-6165

VL - 129

SP - 1275

EP - 1280

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

IS - 10

ER -