TY - JOUR
T1 - Malignant lymphoma of the lacrimal gland
T2 - a nation-based study
AU - Rasmussen, Peter Kristian
AU - Ralfkiaer, Elisabeth
AU - Prause, Jan Ulrik
AU - Sjö, Lene D
AU - Siersma, Volkert D
AU - Heegaard, Steffen
PY - 2011/10
Y1 - 2011/10
N2 - Objective: To characterize the clinicopathologic features of lacrimal gland lymphoma. Methods: All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected. Results: Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43- 87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%. Conclusions: Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.
AB - Objective: To characterize the clinicopathologic features of lacrimal gland lymphoma. Methods: All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected. Results: Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43- 87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%. Conclusions: Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Denmark
KW - Eye Neoplasms
KW - Female
KW - Humans
KW - Lacrimal Apparatus Diseases
KW - Leukemia, Lymphocytic, Chronic, B-Cell
KW - Lymphoma, B-Cell
KW - Lymphoma, Follicular
KW - Lymphoma, Mantle-Cell
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Registries
KW - Survival Rate
KW - Tomography, X-Ray Computed
U2 - 10.1001/archophthalmol.2011.270
DO - 10.1001/archophthalmol.2011.270
M3 - Journal article
C2 - 21987669
SN - 0003-9950
VL - 129
SP - 1275
EP - 1280
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 10
ER -