Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Kai Holland-Nell; Morten Peter Meldal

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Department of Chemistry

83 Citations (Scopus)

Abstract

Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.

Original language	English
Journal	Angewandte Chemie - German Edition
Volume	123
Pages (from-to)	5310–5312
ISSN	0044-8249
Publication status	Published - 23 May 2011

Cite this

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abstract = "Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.",

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AB - Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.

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VL - 123

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JO - Angewandte Chemie - German Edition

JF - Angewandte Chemie - German Edition

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Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Abstract

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