Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Kai Holland-Nell; Morten Peter Meldal

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Kemisk Institut

83 Citationer (Scopus)

Abstract

Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.

Originalsprog	Engelsk
Tidsskrift	Angewandte Chemie - German Edition
Vol/bind	123
Sider (fra-til)	5310–5312
ISSN	0044-8249
Status	Udgivet - 23 maj 2011

Citationsformater

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abstract = "Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.",

author = "Kai Holland-Nell and Meldal, {Morten Peter}",

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AU - Holland-Nell, Kai

AU - Meldal, Morten Peter

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N2 - Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.

AB - Click into place: Tachyplesin-I (TP-I) analogues in which both disulfide bridges (1) have been replaced with triazoles (2) represent structural mimetics of TP-I that display similar or slightly improved antibacterial activity. Optimized structures were obtained by replacing the cysteine residues in TP-I by azido- and alkyno-functionalized amino acids.

M3 - Journal article

SN - 0044-8249

VL - 123

SP - 5310

EP - 5312

JO - Angewandte Chemie - German Edition

JF - Angewandte Chemie - German Edition

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Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

Abstract

Fingeraftryk

Citationsformater