Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

J. M. Møller; E. Santoni-Rugiu; E. Chabanova; V. Løgager; A. B. Hansen; H. S. Thomsen

doi:10.1080/02841850601128959

Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

J. M. Møller^*, E. Santoni-Rugiu, E. Chabanova, V. Løgager, A. B. Hansen, H. S. Thomsen

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.

Original language	English
Journal	Acta Radiologica
Volume	48
Issue number	2
Pages (from-to)	145-149
Number of pages	5
ISSN	0284-1851
DOIs	https://doi.org/10.1080/02841850601128959
Publication status	Published - 16 Mar 2007

Keywords

Abdomen
Bile duct
Liver
MR imaging
Oral contrast agent

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10.1080/02841850601128959

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abstract = "Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.",

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AU - Santoni-Rugiu, E.

AU - Chabanova, E.

AU - Løgager, V.

AU - Hansen, A. B.

AU - Thomsen, H. S.

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AB - Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.

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KW - Bile duct

KW - Liver

KW - MR imaging

KW - Oral contrast agent

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Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

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Keywords

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