Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

TY - JOUR

T1 - Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

AU - Møller, J. M.

AU - Santoni-Rugiu, E.

AU - Chabanova, E.

AU - Løgager, V.

AU - Hansen, A. B.

AU - Thomsen, H. S.

PY - 2007/3/16

Y1 - 2007/3/16

N2 - Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.

AB - Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.

KW - Abdomen

KW - Bile duct

KW - Liver

KW - MR imaging

KW - Oral contrast agent

UR - http://www.scopus.com/inward/record.url?scp=33947176596&partnerID=8YFLogxK

U2 - 10.1080/02841850601128959

DO - 10.1080/02841850601128959

M3 - Journal article

C2 - 17354133

AN - SCOPUS:33947176596

SN - 0284-1851

VL - 48

SP - 145

EP - 149

JO - Acta Radiologica

JF - Acta Radiologica

IS - 2

ER -