Macrocyclic G-quadruplex ligands

TY - JOUR

T1 - Macrocyclic G-quadruplex ligands

AU - Nielsen, M C

AU - Ulven, Trond

PY - 2010/1/1

Y1 - 2010/1/1

N2 - G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.

AB - G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.

M3 - Journal article

SN - 0929-8673

VL - 17

SP - 3438

EP - 3448

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 29

ER -