Abstract
G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.
| Original language | English |
|---|---|
| Journal | Current Medicinal Chemistry |
| Volume | 17 |
| Issue number | 29 |
| Pages (from-to) | 3438-3448 |
| Number of pages | 11 |
| ISSN | 0929-8673 |
| Publication status | Published - 1 Jan 2010 |