Macrocyclic G-quadruplex ligands

M C Nielsen; Trond Ulven

Macrocyclic G-quadruplex ligands

43 Citationer (Scopus)

Abstract

G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.

Originalsprog	Engelsk
Tidsskrift	Current Medicinal Chemistry
Vol/bind	17
Udgave nummer	29
Sider (fra-til)	3438-3448
Antal sider	11
ISSN	0929-8673
Status	Udgivet - 1 jan. 2010

Citationsformater

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abstract = "G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.",

author = "Nielsen, {M C} and Trond Ulven",

year = "2010",

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language = "English",

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TY - JOUR

T1 - Macrocyclic G-quadruplex ligands

AU - Nielsen, M C

AU - Ulven, Trond

PY - 2010/1/1

Y1 - 2010/1/1

N2 - G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.

AB - G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.

M3 - Journal article

SN - 0929-8673

VL - 17

SP - 3438

EP - 3448

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 29

ER -

Macrocyclic G-quadruplex ligands

Abstract

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