Lung cancer screening and video-assisted thoracic surgery

René Horsleben Petersen; Henrik Jessen Hansen; Asger Dirksen; Jesper Holst Pedersen

doi:10.1097/jto.0b013e31824fe942

Lung cancer screening and video-assisted thoracic surgery

René Horsleben Petersen, Henrik Jessen Hansen, Asger Dirksen, Jesper Holst Pedersen

Abstract

Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.

Original language	English
Journal	Journal of Thoracic Oncology
Volume	7
Issue number	6
Pages (from-to)	1026-31
Number of pages	6
ISSN	1556-0864
DOIs	https://doi.org/10.1097/jto.0b013e31824fe942
Publication status	Published - Jun 2012

Keywords

Aged
Belgium/epidemiology
Early Detection of Cancer/methods
Female
Follow-Up Studies
Humans
Lung Neoplasms/diagnosis
Male
Middle Aged
Morbidity/trends
Pneumonectomy/methods
Prospective Studies
Reproducibility of Results
Survival Rate/trends
Thoracic Surgery, Video-Assisted/methods
Time Factors
Tomography, X-Ray Computed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/jto.0b013e31824fe942

http://www.jto.org/article/S155608641533269X/pdf

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title = "Lung cancer screening and video-assisted thoracic surgery",

abstract = "Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.",

keywords = "Aged, Belgium/epidemiology, Early Detection of Cancer/methods, Female, Follow-Up Studies, Humans, Lung Neoplasms/diagnosis, Male, Middle Aged, Morbidity/trends, Pneumonectomy/methods, Prospective Studies, Reproducibility of Results, Survival Rate/trends, Thoracic Surgery, Video-Assisted/methods, Time Factors, Tomography, X-Ray Computed",

author = "Petersen, {Ren{\'e} Horsleben} and Hansen, {Henrik Jessen} and Asger Dirksen and Pedersen, {Jesper Holst}",

year = "2012",

month = jun,

doi = "10.1097/jto.0b013e31824fe942",

language = "English",

volume = "7",

pages = "1026--31",

journal = "Journal of Thoracic Oncology",

issn = "1556-0864",

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TY - JOUR

T1 - Lung cancer screening and video-assisted thoracic surgery

AU - Petersen, René Horsleben

AU - Hansen, Henrik Jessen

AU - Dirksen, Asger

AU - Pedersen, Jesper Holst

PY - 2012/6

Y1 - 2012/6

N2 - Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.

AB - Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.

KW - Aged

KW - Belgium/epidemiology

KW - Early Detection of Cancer/methods

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Lung Neoplasms/diagnosis

KW - Male

KW - Middle Aged

KW - Morbidity/trends

KW - Pneumonectomy/methods

KW - Prospective Studies

KW - Reproducibility of Results

KW - Survival Rate/trends

KW - Thoracic Surgery, Video-Assisted/methods

KW - Time Factors

KW - Tomography, X-Ray Computed

U2 - 10.1097/jto.0b013e31824fe942

DO - 10.1097/jto.0b013e31824fe942

M3 - Journal article

C2 - 22588154

SN - 1556-0864

VL - 7

SP - 1026

EP - 1031

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

IS - 6

ER -

Lung cancer screening and video-assisted thoracic surgery

Abstract

Keywords

UN SDGs

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