TY - JOUR
T1 - Lung cancer screening and video-assisted thoracic surgery
AU - Petersen, René Horsleben
AU - Hansen, Henrik Jessen
AU - Dirksen, Asger
AU - Pedersen, Jesper Holst
PY - 2012/6
Y1 - 2012/6
N2 - Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.
AB - Introduction: The objective of this study is to report the impact of computed tomography (CT) screening on the use of Video-Assisted Thoracic Surgery (VATS) in a randomized screening trial. METHODS: The Danish Lung Cancer Screening Trial is a randomized clinically controlled trial of 4104 smokers and previous smokers who were randomized to either screening with five annual low-dose CT scans or no screening in Copenhagen from 2004 to 2006. The major end point is the effect of CT screening on lung cancer mortality and treatment options. All diagnostic and treatment interventions in both groups were monitored prospectively until 1 to 3 years after the last screening round. RESULTS: By February 1, 2011 68 cases of lung cancer were detected in the screening group. Furthermore, seven patients with a benign nodule underwent surgical treatment because of suspicion of malignancy (12%). Fifty-one of the 68 lung cancer patients were eligible for surgical treatment. Eight patients had open thoracotomy. Of the operations for lung cancer, 84% were performed by VATS in the CT-screened arm, significantly higher than the control arm (p < 0.05). Thirty-six patients had a VATS lobectomy. One patient had a VATS segmentectomy, and four patients had a VATS wedge resection. The seven benign nodules were all treated with VATS. CONCLUSIONS: CT screening seems to facilitate the use of VATS in the treatment of lung cancer with an 84% rate in our data. Furthermore, all benign nodules could be removed by VATS. In our view, a basic requirement for a surgical institution to be involved in lung cancer CT screening is a dedicated VATS program.
KW - Aged
KW - Belgium/epidemiology
KW - Early Detection of Cancer/methods
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Lung Neoplasms/diagnosis
KW - Male
KW - Middle Aged
KW - Morbidity/trends
KW - Pneumonectomy/methods
KW - Prospective Studies
KW - Reproducibility of Results
KW - Survival Rate/trends
KW - Thoracic Surgery, Video-Assisted/methods
KW - Time Factors
KW - Tomography, X-Ray Computed
U2 - 10.1097/jto.0b013e31824fe942
DO - 10.1097/jto.0b013e31824fe942
M3 - Journal article
C2 - 22588154
SN - 1556-0864
VL - 7
SP - 1026
EP - 1031
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 6
ER -
