Low ABCB1 gene expression is an early event in colorectal carcinogenesis

Vibeke Andersen; Ulla Birgitte Vogel; Sine Godiksen; Franz B Frenzel; Mona Sæbø; Julian Hamfjord; Elin Kure; Lotte K Vogel

doi:10.1371/journal.pone.0072119

Low ABCB1 gene expression is an early event in colorectal carcinogenesis

Vibeke Andersen, Ulla Birgitte Vogel, Sine Godiksen, Franz B Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K Vogel

ICMM Section 8

27 Citations (Scopus)

Abstract

The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

Original language	English
Journal	PloS one
Volume	8
Issue number	8
Pages (from-to)	e72119
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0072119
Publication status	Published - 1 Jan 2013

Keywords

Adenoma
Carcinogenesis
Carcinoma
Case-Control Studies
Colon
Colorectal Neoplasms
Female
Gene Expression
Humans
INDEL Mutation
Male
Middle Aged
NF-kappa B p50 Subunit
P-Glycoprotein
Polymorphism, Single Nucleotide
RNA, Messenger

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0072119

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title = "Low ABCB1 gene expression is an early event in colorectal carcinogenesis",

abstract = "The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P",

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AU - Andersen, Vibeke

AU - Vogel, Ulla Birgitte

AU - Godiksen, Sine

AU - Frenzel, Franz B

AU - Sæbø, Mona

AU - Hamfjord, Julian

AU - Kure, Elin

AU - Vogel, Lotte K

PY - 2013/1/1

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N2 - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

AB - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

KW - Adenoma

KW - Carcinogenesis

KW - Carcinoma

KW - Case-Control Studies

KW - Colon

KW - Colorectal Neoplasms

KW - Female

KW - Gene Expression

KW - Humans

KW - INDEL Mutation

KW - Male

KW - Middle Aged

KW - NF-kappa B p50 Subunit

KW - P-Glycoprotein

KW - Polymorphism, Single Nucleotide

KW - RNA, Messenger

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SP - e72119

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 8

ER -

Low ABCB1 gene expression is an early event in colorectal carcinogenesis

Abstract

Keywords

UN SDGs

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