Low ABCB1 gene expression is an early event in colorectal carcinogenesis

TY - JOUR

T1 - Low ABCB1 gene expression is an early event in colorectal carcinogenesis

AU - Andersen, Vibeke

AU - Vogel, Ulla Birgitte

AU - Godiksen, Sine

AU - Frenzel, Franz B

AU - Sæbø, Mona

AU - Hamfjord, Julian

AU - Kure, Elin

AU - Vogel, Lotte K

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

AB - The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

KW - Adenoma

KW - Carcinogenesis

KW - Carcinoma

KW - Case-Control Studies

KW - Colon

KW - Colorectal Neoplasms

KW - Female

KW - Gene Expression

KW - Humans

KW - INDEL Mutation

KW - Male

KW - Middle Aged

KW - NF-kappa B p50 Subunit

KW - P-Glycoprotein

KW - Polymorphism, Single Nucleotide

KW - RNA, Messenger

U2 - 10.1371/journal.pone.0072119

DO - 10.1371/journal.pone.0072119

M3 - Journal article

C2 - 23977225

SN - 1932-6203

VL - 8

SP - e72119

JO - PloS one

JF - PloS one

IS - 8

ER -