Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

Stine Normann Hansen; David Højland Ipsen; Anne Marie Schou-Pedersen; Jens Lykkesfeldt; Pernille Tveden-Nyborg

doi:10.1016/j.neulet.2018.04.014

Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

Stine Normann Hansen, David Højland Ipsen, Anne Marie Schou-Pedersen, Jens Lykkesfeldt, Pernille Tveden-Nyborg^*

^*Corresponding author for this work

Lifepharm

6 Citations (Scopus)

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Abstract

Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca²⁺/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.

Original language	English
Journal	Neuroscience Letters
Volume	676
Pages (from-to)	85-91
Number of pages	7
ISSN	0304-3940
DOIs	https://doi.org/10.1016/j.neulet.2018.04.014
Publication status	Published - 2018

Keywords

Brain-derived neurotrophic factor
Cavia porcellus
Dyslipidemia
Monoaminergic neurotransmitters
Oxidative stress
Synaptic plasticity

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10.1016/j.neulet.2018.04.014Licence: CC BY-NC-ND

Long term Westernized diet leads to region-specific changes in brain signaling mechanismsFinal published version, 683 KBLicence: CC BY-NC-ND

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title = "Long term Westernized diet leads to region-specific changes in brain signaling mechanisms",

abstract = "Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca2+/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.",

keywords = "Brain-derived neurotrophic factor, Cavia porcellus, Dyslipidemia, Monoaminergic neurotransmitters, Oxidative stress, Synaptic plasticity",

author = "Hansen, {Stine Normann} and Ipsen, {David H{\o}jland} and Schou-Pedersen, {Anne Marie} and Jens Lykkesfeldt and Pernille Tveden-Nyborg",

year = "2018",

doi = "10.1016/j.neulet.2018.04.014",

language = "English",

volume = "676",

pages = "85--91",

journal = "Neuroscience Letters",

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T1 - Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

AU - Hansen, Stine Normann

AU - Ipsen, David Højland

AU - Schou-Pedersen, Anne Marie

AU - Lykkesfeldt, Jens

AU - Tveden-Nyborg, Pernille

PY - 2018

Y1 - 2018

N2 - Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca2+/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.

AB - Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca2+/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.

KW - Brain-derived neurotrophic factor

KW - Cavia porcellus

KW - Dyslipidemia

KW - Monoaminergic neurotransmitters

KW - Oxidative stress

KW - Synaptic plasticity

U2 - 10.1016/j.neulet.2018.04.014

DO - 10.1016/j.neulet.2018.04.014

M3 - Journal article

C2 - 29655945

AN - SCOPUS:85045474766

SN - 0304-3940

VL - 676

SP - 85

EP - 91

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

Abstract

Keywords

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