Abstract
BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.
METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.
RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).
CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.
| Original language | English |
|---|---|
| Journal | B J C |
| Volume | 114 |
| Issue number | 7 |
| Pages (from-to) | 809-812 |
| Number of pages | 4 |
| ISSN | 0007-0920 |
| DOIs | |
| Publication status | Published - 1 Mar 2016 |
Keywords
- Adolescent
- Adult
- Case-Control Studies
- Denmark
- Endometrial Neoplasms
- Female
- Follow-Up Studies
- Humans
- Incidence
- Middle Aged
- Pre-Eclampsia
- Pregnancy
- Prognosis
- Risk Factors
- Young Adult
- Comparative Study
- Journal Article
- Randomized Controlled Trial
- Research Support, Non-U.S. Gov't
