Abstract
BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.
METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.
RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).
CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | B J C |
| Vol/bind | 114 |
| Udgave nummer | 7 |
| Sider (fra-til) | 809-812 |
| Antal sider | 4 |
| ISSN | 0007-0920 |
| DOI | |
| Status | Udgivet - 1 mar. 2016 |
FN’s Verdensmål
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