Long-term impact of preeclampsia on maternal endometrial cancer risk

TY - JOUR

T1 - Long-term impact of preeclampsia on maternal endometrial cancer risk

AU - Hallum, Sara

AU - Pinborg, Anja

AU - Kamper-Jørgensen, Mads

PY - 2016/3/1

Y1 - 2016/3/1

N2 - BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.

AB - BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.

KW - Adolescent

KW - Adult

KW - Case-Control Studies

KW - Denmark

KW - Endometrial Neoplasms

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Middle Aged

KW - Pre-Eclampsia

KW - Pregnancy

KW - Prognosis

KW - Risk Factors

KW - Young Adult

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/bjc.2016.55

DO - 10.1038/bjc.2016.55

M3 - Letter

C2 - 26964032

SN - 0007-0920

VL - 114

SP - 809

EP - 812

JO - B J C

JF - B J C

IS - 7

ER -