Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure

Charlotte Andersson; Peter Weeke; Redi Pecini; Jesper Kjaergaard; Christian Hassager; Lars Køber; Christian Torp-Pedersen; Charlotte Andersson; Peter Weeke; Redi Pecini; Jesper Kjaergaard; Christian Hassager; Lars Køber; Christian Torp-Pedersen

doi:10.3109/14017430903312438

Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure

Charlotte Andersson, Peter Weeke, Redi Pecini, Jesper Kjaergaard, Christian Hassager, Lars Køber, Christian Torp-Pedersen, Charlotte Andersson, Peter Weeke, Redi Pecini, Jesper Kjaergaard, Christian Hassager, Lars Køber, Christian Torp-Pedersen

17 Citations (Scopus)

Abstract

Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.

Original language	English
Journal	Scandinavian Cardiovascular Journal
Volume	44
Issue number	1
Pages (from-to)	37-44
Number of pages	8
ISSN	1401-7431
DOIs	https://doi.org/10.3109/14017430903312438
Publication status	Published - 1 Feb 2010

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Andersson, C., Weeke, P., Pecini, R., Kjaergaard, J., Hassager, C., Køber, L., Torp-Pedersen, C., Andersson, C., Weeke, P., Pecini, R., Kjaergaard, J., Hassager, C., Køber, L., & Torp-Pedersen, C. (2010). Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure. Scandinavian Cardiovascular Journal, 44(1), 37-44. https://doi.org/10.3109/14017430903312438

Andersson, C, Weeke, P, Pecini, R, Kjaergaard, J, Hassager, C , Køber, L , Torp-Pedersen, C, Andersson, C, Weeke, P, Pecini, R, Kjaergaard, J, Hassager, C, Køber, L & Torp-Pedersen, C 2010, 'Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure', Scandinavian Cardiovascular Journal, vol. 44, no. 1, pp. 37-44. https://doi.org/10.3109/14017430903312438

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abstract = "Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.",

author = "Charlotte Andersson and Peter Weeke and Redi Pecini and Jesper Kjaergaard and Christian Hassager and Lars K{\o}ber and Christian Torp-Pedersen and Charlotte Andersson and Peter Weeke and Redi Pecini and Jesper Kjaergaard and Christian Hassager and Lars K{\o}ber and Christian Torp-Pedersen",

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AU - Weeke, Peter

AU - Pecini, Redi

AU - Kjaergaard, Jesper

AU - Hassager, Christian

AU - Køber, Lars

AU - Torp-Pedersen, Christian

AU - Andersson, Charlotte

AU - Weeke, Peter

AU - Pecini, Redi

AU - Kjaergaard, Jesper

AU - Hassager, Christian

AU - Køber, Lars

AU - Torp-Pedersen, Christian

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N2 - Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.

AB - Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.

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DO - 10.3109/14017430903312438

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EP - 44

JO - Scandinavian Cardiovascular Journal, Supplement

JF - Scandinavian Cardiovascular Journal, Supplement

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Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure

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