TY - JOUR
T1 - Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure
AU - Andersson, Charlotte
AU - Weeke, Peter
AU - Pecini, Redi
AU - Kjaergaard, Jesper
AU - Hassager, Christian
AU - Køber, Lars
AU - Torp-Pedersen, Christian
AU - Andersson, Charlotte
AU - Weeke, Peter
AU - Pecini, Redi
AU - Kjaergaard, Jesper
AU - Hassager, Christian
AU - Køber, Lars
AU - Torp-Pedersen, Christian
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.
AB - Objectives. Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. Design. One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. Results. Mean age was 73 (± standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.221.73, p < 0.0001) if ischemic HF, and 1.50 (1.221.84, p < 0.0001) if non-ischemic HF (p for interaction 0.4), compared to non-DM non-ischemic HF patients. Conclusion. The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.
U2 - 10.3109/14017430903312438
DO - 10.3109/14017430903312438
M3 - Journal article
C2 - 19878095
SN - 1401-7458
VL - 44
SP - 37
EP - 44
JO - Scandinavian Cardiovascular Journal, Supplement
JF - Scandinavian Cardiovascular Journal, Supplement
IS - 1
ER -
