TY - JOUR
T1 - Long-term effects of foetal undernutrition on intermediary metabolism in growing lambs
AU - Kiani, Ali
AU - Nielsen, Mette Benedicte Olaf
AU - Tauson, Anne-Helene
AU - Tygesen, Malin Plumhoff
AU - Husted, Sanne Vinter
AU - Chwalibog, André
PY - 2011/2
Y1 - 2011/2
N2 - The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose mothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, non-esterified fatty acids (NEFA), 3-b-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 + 0.03 vs. 1.9 + 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 + 0.02 mM) was significantly higher than that in AN lambs (0.78 + 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in ketone body metabolism potentially induced by under-nutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.
AB - The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose mothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, non-esterified fatty acids (NEFA), 3-b-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 + 0.03 vs. 1.9 + 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 + 0.02 mM) was significantly higher than that in AN lambs (0.78 + 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in ketone body metabolism potentially induced by under-nutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.
KW - Former LIFE faculty
KW - metabolic programming
KW - metabolites
KW - fasting
KW - sheep
U2 - 10.1080/1745039x.2010.533551
DO - 10.1080/1745039x.2010.533551
M3 - Journal article
SN - 1745-039X
VL - 65
SP - 46
EP - 54
JO - Archives of Animal Nutrition
JF - Archives of Animal Nutrition
IS - 1
ER -
