Long-term effects of foetal undernutrition on intermediary metabolism in growing lambs

TY - JOUR

T1 - Long-term effects of foetal undernutrition on intermediary metabolism in growing lambs

AU - Kiani, Ali

AU - Nielsen, Mette Benedicte Olaf

AU - Tauson, Anne-Helene

AU - Tygesen, Malin Plumhoff

AU - Husted, Sanne Vinter

AU - Chwalibog, André

PY - 2011/2

Y1 - 2011/2

N2 - The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose mothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, non-esterified fatty acids (NEFA), 3-b-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 + 0.03 vs. 1.9 + 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 + 0.02 mM) was significantly higher than that in AN lambs (0.78 + 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in ketone body metabolism potentially induced by under-nutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.

AB - The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose mothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, non-esterified fatty acids (NEFA), 3-b-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 + 0.03 vs. 1.9 + 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 + 0.02 mM) was significantly higher than that in AN lambs (0.78 + 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in ketone body metabolism potentially induced by under-nutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.

KW - Former LIFE faculty

KW - metabolic programming

KW - metabolites

KW - fasting

KW - sheep

U2 - 10.1080/1745039x.2010.533551

DO - 10.1080/1745039x.2010.533551

M3 - Journal article

SN - 1745-039X

VL - 65

SP - 46

EP - 54

JO - Archives of Animal Nutrition

JF - Archives of Animal Nutrition

IS - 1

ER -