Liver failure in neonatal children is a diagnostic challenge

Heidi Smedegaard; Vibeke Brix Christensen; Morten Hanefeld Dziegiel; Marianne Hørby Jørgensen

Liver failure in neonatal children is a diagnostic challenge

Heidi Smedegaard, Vibeke Brix Christensen, Morten Hanefeld Dziegiel, Marianne Hørby Jørgensen

Abstract

This case report presents a newborn boy with hypoglycaemia, anaemia, jaundice and severe coagulopathy during the first day of his life, imitating sepsis and disseminated intravascular coagulation. One week after the birth he was diagnosed with acute liver failure due to gestational alloimmune liver disease (GALD). Despite the fact that GALD is rare, it must be suspected in all unexplained stillborn children and infants with severe liver disease. If diagnosed, it is possible to prevent death and severe liver failure in future newborns by treating the affected women with immunoglobulin during pregnancy.

Original language	English
Journal	Ugeskrift for Laeger
Volume	179
Issue number	13
ISSN	0041-5782
Publication status	Published - 27 Mar 2017

Cite this

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title = "Liver failure in neonatal children is a diagnostic challenge",

abstract = "This case report presents a newborn boy with hypoglycaemia, anaemia, jaundice and severe coagulopathy during the first day of his life, imitating sepsis and disseminated intravascular coagulation. One week after the birth he was diagnosed with acute liver failure due to gestational alloimmune liver disease (GALD). Despite the fact that GALD is rare, it must be suspected in all unexplained stillborn children and infants with severe liver disease. If diagnosed, it is possible to prevent death and severe liver failure in future newborns by treating the affected women with immunoglobulin during pregnancy.",

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AU - Smedegaard, Heidi

AU - Christensen, Vibeke Brix

AU - Dziegiel, Morten Hanefeld

AU - Jørgensen, Marianne Hørby

PY - 2017/3/27

Y1 - 2017/3/27

N2 - This case report presents a newborn boy with hypoglycaemia, anaemia, jaundice and severe coagulopathy during the first day of his life, imitating sepsis and disseminated intravascular coagulation. One week after the birth he was diagnosed with acute liver failure due to gestational alloimmune liver disease (GALD). Despite the fact that GALD is rare, it must be suspected in all unexplained stillborn children and infants with severe liver disease. If diagnosed, it is possible to prevent death and severe liver failure in future newborns by treating the affected women with immunoglobulin during pregnancy.

AB - This case report presents a newborn boy with hypoglycaemia, anaemia, jaundice and severe coagulopathy during the first day of his life, imitating sepsis and disseminated intravascular coagulation. One week after the birth he was diagnosed with acute liver failure due to gestational alloimmune liver disease (GALD). Despite the fact that GALD is rare, it must be suspected in all unexplained stillborn children and infants with severe liver disease. If diagnosed, it is possible to prevent death and severe liver failure in future newborns by treating the affected women with immunoglobulin during pregnancy.

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VL - 179

JO - Ugeskrift for Laeger

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ER -

Liver failure in neonatal children is a diagnostic challenge

Abstract

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