Lipases, liposomes and lipid-prodrugs

Ahmad Arouri; Anders Højgaard Hansen; Thomas Elmelund Rasmussen; Ole G. Mouritsen

doi:10.1016/j.cocis.2013.06.001

Lipases, liposomes and lipid-prodrugs

Ahmad Arouri, Anders Højgaard Hansen, Thomas Elmelund Rasmussen, Ole G. Mouritsen^*

^*Corresponding author for this work

45 Citations (Scopus)

Abstract

Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

Original language	English
Journal	Current Opinion in Colloid and Interface Science
Volume	18
Issue number	5
Pages (from-to)	419-431
Number of pages	13
ISSN	1359-0294
DOIs	https://doi.org/10.1016/j.cocis.2013.06.001
Publication status	Published - 1 Oct 2013

Keywords

Drug delivery
Interface
Liposome
Phospholipase
Prodrug

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cocis.2013.06.001

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AU - Arouri, Ahmad

AU - Hansen, Anders Højgaard

AU - Rasmussen, Thomas Elmelund

AU - Mouritsen, Ole G.

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Y1 - 2013/10/1

N2 - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

AB - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

KW - Drug delivery

KW - Interface

KW - Liposome

KW - Phospholipase

KW - Prodrug

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M3 - Review

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EP - 431

JO - Current Opinion in Colloid & Interface Science

JF - Current Opinion in Colloid & Interface Science

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Lipases, liposomes and lipid-prodrugs

Abstract

Keywords

UN SDGs

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