Lipases, liposomes and lipid-prodrugs

Ahmad Arouri; Anders Højgaard Hansen; Thomas Elmelund Rasmussen; Ole G. Mouritsen

doi:10.1016/j.cocis.2013.06.001

Lipases, liposomes and lipid-prodrugs

Ahmad Arouri, Anders Højgaard Hansen, Thomas Elmelund Rasmussen, Ole G. Mouritsen^*

^*Corresponding author af dette arbejde

45 Citationer (Scopus)

Abstract

Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Colloid and Interface Science
Vol/bind	18
Udgave nummer	5
Sider (fra-til)	419-431
Antal sider	13
ISSN	1359-0294
DOI	https://doi.org/10.1016/j.cocis.2013.06.001
Status	Udgivet - 1 okt. 2013

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abstract = "Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.",

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AU - Arouri, Ahmad

AU - Hansen, Anders Højgaard

AU - Rasmussen, Thomas Elmelund

AU - Mouritsen, Ole G.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

AB - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

KW - Drug delivery

KW - Interface

KW - Liposome

KW - Phospholipase

KW - Prodrug

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U2 - 10.1016/j.cocis.2013.06.001

DO - 10.1016/j.cocis.2013.06.001

M3 - Review

AN - SCOPUS:84882264988

SN - 1359-0294

VL - 18

SP - 419

EP - 431

JO - Current Opinion in Colloid & Interface Science

JF - Current Opinion in Colloid & Interface Science

IS - 5

ER -

Lipases, liposomes and lipid-prodrugs

Abstract

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