Lipases, liposomes and lipid-prodrugs

TY - JOUR

T1 - Lipases, liposomes and lipid-prodrugs

AU - Arouri, Ahmad

AU - Hansen, Anders Højgaard

AU - Rasmussen, Thomas Elmelund

AU - Mouritsen, Ole G.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

AB - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

KW - Drug delivery

KW - Interface

KW - Liposome

KW - Phospholipase

KW - Prodrug

UR - http://www.scopus.com/inward/record.url?scp=84882264988&partnerID=8YFLogxK

U2 - 10.1016/j.cocis.2013.06.001

DO - 10.1016/j.cocis.2013.06.001

M3 - Review

AN - SCOPUS:84882264988

SN - 1359-0294

VL - 18

SP - 419

EP - 431

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

IS - 5

ER -