Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders; Michael Baudis; Regina Becker; Sergi Beltran; Christophe Béroud; Ewan Birney; Cath Brooksbank; Søren Brunak; Marc Van den Bulcke; Rachel Drysdale; Salvador Capella-Gutierrez; Paul Flicek; Francesco Florindi; Peter Goodhand; Ivo Gut; Jaap Heringa; Petr Holub; Jef Hooyberghs; Nick Juty; Thomas M Keane; Jan O Korbel; Ilkka Lappalainen; Brane Leskosek; Gert Matthijs; Michaela Th Mayrhofer; Andres Metspalu; Arcadi Navarro; Steven Newhouse; Tommi Nyrönen; Angela Page; Bengt Persson; Aarno Palotie; Helen Parkinson; Jordi Rambla; David Salgado; Erik Steinfelder; Morris A Swertz; Alfonso Valencia; Susheel Varma; Niklas Blomberg; Serena Scollen

doi:10.1038/s41576-019-0156-9

Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders, Michael Baudis, Regina Becker, Sergi Beltran, Christophe Béroud, Ewan Birney, Cath Brooksbank, Søren Brunak, Marc Van den Bulcke, Rachel Drysdale, Salvador Capella-Gutierrez, Paul Flicek, Francesco Florindi, Peter Goodhand, Ivo Gut, Jaap Heringa, Petr Holub, Jef Hooyberghs, Nick Juty, Thomas M KeaneJan O Korbel, Ilkka Lappalainen, Brane Leskosek, Gert Matthijs, Michaela Th Mayrhofer, Andres Metspalu, Arcadi Navarro, Steven Newhouse, Tommi Nyrönen, Angela Page, Bengt Persson, Aarno Palotie, Helen Parkinson, Jordi Rambla, David Salgado, Erik Steinfelder, Morris A Swertz, Alfonso Valencia, Susheel Varma, Niklas Blomberg, Serena Scollen

Disease Systems Biology Program

14 Citationer (Scopus)

Abstract

Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews. Genetics
Vol/bind	20
Sider (fra-til)	693-701
Antal sider	9
ISSN	1471-0056
DOI	https://doi.org/10.1038/s41576-019-0156-9
Status	Udgivet - 1 nov. 2019

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10.1038/s41576-019-0156-9

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Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., ... Scollen, S. (2019). Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews. Genetics, 20, 693-701. https://doi.org/10.1038/s41576-019-0156-9

Saunders, G, Baudis, M, Becker, R, Beltran, S, Béroud, C, Birney, E, Brooksbank, C, Brunak, S, Van den Bulcke, M, Drysdale, R, Capella-Gutierrez, S, Flicek, P, Florindi, F, Goodhand, P, Gut, I, Heringa, J, Holub, P, Hooyberghs, J, Juty, N, Keane, TM, Korbel, JO, Lappalainen, I, Leskosek, B, Matthijs, G, Mayrhofer, MT, Metspalu, A, Navarro, A, Newhouse, S, Nyrönen, T, Page, A, Persson, B, Palotie, A, Parkinson, H, Rambla, J, Salgado, D, Steinfelder, E, Swertz, MA, Valencia, A, Varma, S, Blomberg, N & Scollen, S 2019, 'Leveraging European infrastructures to access 1 million human genomes by 2022', Nature Reviews. Genetics, bind 20, s. 693-701. https://doi.org/10.1038/s41576-019-0156-9

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AU - Béroud, Christophe

AU - Birney, Ewan

AU - Brooksbank, Cath

AU - Brunak, Søren

AU - Van den Bulcke, Marc

AU - Drysdale, Rachel

AU - Capella-Gutierrez, Salvador

AU - Flicek, Paul

AU - Florindi, Francesco

AU - Goodhand, Peter

AU - Gut, Ivo

AU - Heringa, Jaap

AU - Holub, Petr

AU - Hooyberghs, Jef

AU - Juty, Nick

AU - Keane, Thomas M

AU - Korbel, Jan O

AU - Lappalainen, Ilkka

AU - Leskosek, Brane

AU - Matthijs, Gert

AU - Mayrhofer, Michaela Th

AU - Metspalu, Andres

AU - Navarro, Arcadi

AU - Newhouse, Steven

AU - Nyrönen, Tommi

AU - Page, Angela

AU - Persson, Bengt

AU - Palotie, Aarno

AU - Parkinson, Helen

AU - Rambla, Jordi

AU - Salgado, David

AU - Steinfelder, Erik

AU - Swertz, Morris A

AU - Valencia, Alfonso

AU - Varma, Susheel

AU - Blomberg, Niklas

AU - Scollen, Serena

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Leveraging European infrastructures to access 1 million human genomes by 2022

Abstract

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