Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

Cameron Keith McDonald; Mikkel Z. Ankarfeldt; Sandra Capra; Judy Bauer; Kyle Raymond; Berit Lilienthal Heitmann

doi:10.1017/s0007114516000611

Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

Cameron Keith McDonald, Mikkel Z. Ankarfeldt, Sandra Capra, Judy Bauer, Kyle Raymond, Berit Lilienthal Heitmann

Department of Public Health

27 Citations (Scopus)

Abstract

Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results.

Original language	English
Journal	British Journal of Nutrition
Volume	115
Issue number	9
Pages (from-to)	1556-1562
Number of pages	7
ISSN	0007-1145
DOIs	https://doi.org/10.1017/s0007114516000611
Publication status	Published - 14 May 2016

Keywords

Absorptiometry, Photon
Adult
Age Factors
Aged
Aging
Body Composition
Body Fluid Compartments
Cardiovascular Diseases
Cohort Studies
Denmark
Diet
Dietary Proteins
Electric Impedance
Energy Intake
Exercise
Female
Humans
Leucine
Male
Middle Aged
Muscle, Skeletal
Sarcopenia
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population",

abstract = "Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results.",

keywords = "Absorptiometry, Photon, Adult, Age Factors, Aged, Aging, Body Composition, Body Fluid Compartments, Cardiovascular Diseases, Cohort Studies, Denmark, Diet, Dietary Proteins, Electric Impedance, Energy Intake, Exercise, Female, Humans, Leucine, Male, Middle Aged, Muscle, Skeletal, Sarcopenia, Journal Article",

author = "McDonald, {Cameron Keith} and Ankarfeldt, {Mikkel Z.} and Sandra Capra and Judy Bauer and Kyle Raymond and Heitmann, {Berit Lilienthal}",

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T1 - Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

AU - McDonald, Cameron Keith

AU - Ankarfeldt, Mikkel Z.

AU - Capra, Sandra

AU - Bauer, Judy

AU - Raymond, Kyle

AU - Heitmann, Berit Lilienthal

PY - 2016/5/14

Y1 - 2016/5/14

N2 - Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results.

AB - Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results.

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KW - Age Factors

KW - Aged

KW - Aging

KW - Body Composition

KW - Body Fluid Compartments

KW - Cardiovascular Diseases

KW - Cohort Studies

KW - Denmark

KW - Diet

KW - Dietary Proteins

KW - Electric Impedance

KW - Energy Intake

KW - Exercise

KW - Female

KW - Humans

KW - Leucine

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - Sarcopenia

KW - Journal Article

U2 - 10.1017/s0007114516000611

DO - 10.1017/s0007114516000611

M3 - Journal article

C2 - 26979049

SN - 0007-1145

VL - 115

SP - 1556

EP - 1562

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 9

ER -

Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

Abstract

Keywords

UN SDGs

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