Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion

A Johansen; E-M D Nielsen; G Andersen; Y H Hamid; D P Jensen; C Glümer; T Drivsholm; K Borch-Johnsen; T Jørgensen; T Hansen; O Pedersen

doi:10.1007/s00125-004-1459-7

Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion

A Johansen, E-M D Nielsen, G Andersen, Y H Hamid, D P Jensen, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

24 Citations (Scopus)

Abstract

Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. The objectives of our study were to examine whether the BCHE K variant is associated with Type 2 diabetes or estimates of pancreatic beta cell function in large-scale populations of glucose-tolerant Caucasians.

Original language	English
Journal	Diabetologia
Volume	47
Issue number	8
Pages (from-to)	1437-41
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-004-1459-7
Publication status	Published - 1 Aug 2004

Keywords

Amino Acid Substitution
Base Sequence
Blood Glucose
Butyrylcholinesterase
DNA Primers
Diabetes Mellitus, Type 2
Gene Frequency
Genetic Variation
Genotype
Humans
Insulin
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Reference Values

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-004-1459-7

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Johansen, A., Nielsen, E.-M. D., Andersen, G., Hamid, Y. H., Jensen, D. P., Glümer, C., Drivsholm, T., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2004). Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion. Diabetologia, 47(8), 1437-41. https://doi.org/10.1007/s00125-004-1459-7

Johansen, A, Nielsen, E-MD, Andersen, G, Hamid, YH, Jensen, DP, Glümer, C, Drivsholm, T, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2004, 'Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion', Diabetologia, vol. 47, no. 8, pp. 1437-41. https://doi.org/10.1007/s00125-004-1459-7

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abstract = "Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. The objectives of our study were to examine whether the BCHE K variant is associated with Type 2 diabetes or estimates of pancreatic beta cell function in large-scale populations of glucose-tolerant Caucasians.",

keywords = "Amino Acid Substitution, Base Sequence, Blood Glucose, Butyrylcholinesterase, DNA Primers, Diabetes Mellitus, Type 2, Gene Frequency, Genetic Variation, Genotype, Humans, Insulin, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Reference Values",

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AU - Johansen, A

AU - Nielsen, E-M D

AU - Andersen, G

AU - Hamid, Y H

AU - Jensen, D P

AU - Glümer, C

AU - Drivsholm, T

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Pedersen, O

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AB - Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. The objectives of our study were to examine whether the BCHE K variant is associated with Type 2 diabetes or estimates of pancreatic beta cell function in large-scale populations of glucose-tolerant Caucasians.

KW - Amino Acid Substitution

KW - Base Sequence

KW - Blood Glucose

KW - Butyrylcholinesterase

KW - DNA Primers

KW - Diabetes Mellitus, Type 2

KW - Gene Frequency

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Insulin

KW - Polymerase Chain Reaction

KW - Polymorphism, Restriction Fragment Length

KW - Polymorphism, Single Nucleotide

KW - Reference Values

U2 - 10.1007/s00125-004-1459-7

DO - 10.1007/s00125-004-1459-7

M3 - Journal article

C2 - 15258737

SN - 0012-186X

VL - 47

SP - 1437

EP - 1441

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion

Abstract

Keywords

UN SDGs

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