Abstract
Gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 [7-36 amide] (GLP-1) are glucose-dependent insulinotropic gut hormones. Under experimental conditions, both have been shown to reduce stimulated gastric acid secretion. To study their individual and combined effects on pentagastrin-stimulated (0.1 micrograms/kg/h from -90 to 120 min) gastric volume, acid and chloride output, on separate occasions, synthetic human GIP (1 pmol/kg/min) and/or GLP-1 [7-36 amide] (0.3 pmol/kg/min) or placebo (0.9% NaCl with 1% albumin) were infused intravenously (from -30 to 120 min) in 9 healthy volunteers. At 0 min, a glucose infusion was started that mimicked the glycemic profile after an oral glucose load of 50 g/400 ml and allowed for the glucose-dependent insulinotropic action of GIP and GLP-1 [7-36 amide]. Pentagastrin stimulated acid output significantly, but neither GIP nor GLP-1 [7-36 amide] either alone or in combination, reduced pentagastrin-stimulated gastric acid secretion. The circulating concentrations of GIP and GLP-1 [7-36 amide] obtained at steady state during exogenous administration of synthetic peptides were similar to or higher than those reached after oral glucose (endogenous secretion). In conclusion, (penta)gastrin-stimulated gastric acid secretion is not inhibited by physiological circulating concentrations of GIP or GLP-1 [7-36 amide]. Therefore, the insulinotropic action of these intestinal hormones is physiologically more important than their possible role as enterogastrone.
Original language | English |
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Journal | Digestion |
Volume | 52 |
Issue number | 3-4 |
Pages (from-to) | 214-21 |
Number of pages | 8 |
ISSN | 0012-2823 |
DOIs | |
Publication status | Published - 1992 |
Keywords
- Adult
- Blood Glucose/metabolism
- Gastric Acid/secretion
- Gastric Inhibitory Polypeptide/physiology
- Glucagon/physiology
- Glucagon-Like Peptide 1
- Glucagon-Like Peptides
- Hormones/pharmacology
- Humans
- Infusions, Intravenous
- Male
- Pentagastrin/pharmacology
- Peptide Fragments/physiology
- Stimulation, Chemical