Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects

M A Nauck, E Bartels, C Orskov, R Ebert, W Creutzfeldt

40 Citations (Scopus)

Abstract

Gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 [7-36 amide] (GLP-1) are glucose-dependent insulinotropic gut hormones. Under experimental conditions, both have been shown to reduce stimulated gastric acid secretion. To study their individual and combined effects on pentagastrin-stimulated (0.1 micrograms/kg/h from -90 to 120 min) gastric volume, acid and chloride output, on separate occasions, synthetic human GIP (1 pmol/kg/min) and/or GLP-1 [7-36 amide] (0.3 pmol/kg/min) or placebo (0.9% NaCl with 1% albumin) were infused intravenously (from -30 to 120 min) in 9 healthy volunteers. At 0 min, a glucose infusion was started that mimicked the glycemic profile after an oral glucose load of 50 g/400 ml and allowed for the glucose-dependent insulinotropic action of GIP and GLP-1 [7-36 amide]. Pentagastrin stimulated acid output significantly, but neither GIP nor GLP-1 [7-36 amide] either alone or in combination, reduced pentagastrin-stimulated gastric acid secretion. The circulating concentrations of GIP and GLP-1 [7-36 amide] obtained at steady state during exogenous administration of synthetic peptides were similar to or higher than those reached after oral glucose (endogenous secretion). In conclusion, (penta)gastrin-stimulated gastric acid secretion is not inhibited by physiological circulating concentrations of GIP or GLP-1 [7-36 amide]. Therefore, the insulinotropic action of these intestinal hormones is physiologically more important than their possible role as enterogastrone.

Original languageEnglish
JournalDigestion
Volume52
Issue number3-4
Pages (from-to)214-21
Number of pages8
ISSN0012-2823
DOIs
Publication statusPublished - 1992

Keywords

  • Adult
  • Blood Glucose/metabolism
  • Gastric Acid/secretion
  • Gastric Inhibitory Polypeptide/physiology
  • Glucagon/physiology
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptides
  • Hormones/pharmacology
  • Humans
  • Infusions, Intravenous
  • Male
  • Pentagastrin/pharmacology
  • Peptide Fragments/physiology
  • Stimulation, Chemical

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